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GREGORY N. BARNES, MD, PhD

SPECIALTY / DISCIPLINE:

Neurology with Special Qualifications in Child Neurology

EDUCATION:

Medical Degree | University of Kentucky College of Medicine

Internship | Pediatrics | St. Louis Children's Hospital

Residency | Pediatrics | St. Louis Children's Hospital

Fellowship | Pediatric Neurology | Boston Children's Hospital

SERVICE FOCUS / AREAS OF INTEREST:

Neurology with Special Qualifications in Child Neurology

PUBLICATIONS:

Manuscripts/ Monographs
Research Articles
1. Barnes, G., Slevin, J., & Vanaman, T. (2002). Rat brain protein phosphatase 2A: An enzyme that may regulate autophosphorylated protein kinases. Journal of Neurochemistry, 64(1), 340-353. doi:10.1046/j.1471-4159.1995.64010340.x

Online: http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.1995.64010340.x/abstract;jsessionid=8D2E929B36F8649693AC233FFD78154A.f04t03


2. Barnes, G.N., Martinez-Arizala, A., et al [The Transverse Myelitis Consortium Working Group] (2002) Proposed Diagnostic and Nosology Criteria for Acute Transverse Myelitis, Neurology, 59 (4): 499-504


3. Barnes G.N., Ma, M.H., Pulliam, J., Baumann, R., and Berger, J.R. (2002) CNS Granulomatous Angitis in Chronic Graft vs. Host Disease following Bone Marrow Transplant, Neurology, 59 (12): 1994-1997


4. Barnes, G.N., Puranam, R., Luo, Y.L.,& McNamara, J.O. (2003) Anatomical and Temporal Specific Patterns of Semaphorin Gene Expression in Rat Brain after Kainic Acid Induced Status Epilepticus, Hippocampus, 13:1-20


5. Barnes, G.N. and Slevin, J.T. (2003) Glutamate Receptor Biology: Effect on Synaptic Connectivity and Function, Current Medicinal Chemistry, 10: 2059-2073


6. Yang, J., Houk, B, Shah, J.P., Hauser, K.F., Luo, Y.L, Smith, G.M., Schauwecker, P.E., and Barnes, G.N. (2005) Genetic Background Regulates Semaphorin Gene Expression and Epileptogenesis in Mouse Brain after Kainic Acid Status Epilepticus, Neuroscience 131 (4): 853-969


7. JA Paolicchi and G.N. Barnes (2008) Neuropsychiatric Comorbidities in Childhood Absence Epilepsy, Nature Clinical Practice Neurology, 4(12):650-1.


8. Gant, J. C., Thibault, O., Blalock, E. M., J. Yang, A. Bachstetter, J. Kotick, P.E. Schauwecker, K.F. Hauser, G.M. Smith, Mervis, R., and G. N. Barnes (2009) Decreased Number of Interneurons and Increased Seizures in Neuropilin 2 Deficient Mice: Implications for Autism and Epilepsy, Epilepsia, 50(4):629-45.


9. G.N Barnes (2009) Postnatal Influences on Seizure Susceptibility: Does My Mother Really Matter? Epilepsy Currents Nov/Dec 2009, 9(6):176-8.

10. G.N Barnes (2010) “For Whom the Bell Tolls”: Blockade Agents of Toll-Like Receptors May Regulate Seizure Occurrence, Epilepsy Currents 2010 Nov; 10(6):164-5.


11. Perdigoto, A.L., Chaudry, N., Filbin, M.T., Barnes, G.N., and Carter, B.D. (2011) A Novel Role for PTEN in the Inhibition of Neurite Outgrowth by Myelin-associated Glycoprotein in Cortical Neurons, Mol. Cell. Neurosci., 46(1):235-44.


12. Vendrame, M, Loddenkemper, T, Zarowski, M, Gregas, M, Shuhaiber, H, Sarco, D.P., Morales, A., Nespeca, M., Sharpe, C., Haas, K, Barnes, G.N., Glaze, D., Kothare, S. (2012) Analysis of EEG patterns and genotype in patients with Angelman Syndrome. Epilepsy and Behavior, 23(3):261-5.


13. Kang, Q. and Barnes, G.N. (2013) A common susceptibility factor for autism and epilepsy: functional deficiency of GABAA receptors, J. Autism Develop. Disorders, 43(1):68-79.


14. Sidhu, R., Velaydum, K., and Barnes, G.N. (2013) Pediatric Seizures, Pediatrics in Review, 34(8):333-42.


15. Robinson, A, Goldman, S, Barnes, G.N., and Malow, B. (2014) Electroencephalogram (EEG) Duration Needed to Detect Abnormalities in Angelman Syndrome: Is One Hour of Overnight Recording Sufficient?, J. Child Neurology, in press

Chapters in Books/Monographs
1. Barnes, G.N. (1990) The role of calcium dependent protein kinases and protein phosphatase 2A in the kindling model of epilepsy. PhD thesis, University of Kentucky]


2. Barnes, G.N. and Slevin, J.T. (2005) “Effect of Genetic Background on Ionotropic Glutamate Receptor and Neurotrophin Biology: Synaptic Connectivity and Function in Neurological Disease”, Frontiers in Medicinal Chemistry (Volume 1), editors Drs. Allen B. Reitz, Cheryl P. Kordik, M. Iqbal Choudhary, & Atta –ur- Rahman, Bentham Science Publishers, in press


3. Barnes, G.N. and Fenichel, G.M. (2006) “Neonatal Seizures” in Neonatal Neurology, 4th edition, editor Dr. Gerald M. Fenichel, Harcourt Publishers Ltd, London, England


4. Barnes, G.N. and Fenichel, G.M. (2006) “Neonatal Electroencephalography” in Neonatal Neurology, 4th edition, editor Dr. Gerald M. Fenichel, Harcourt Publishers Ltd, London, England


5. Hauser, K.F., N. El-Hage, S. Buch, G.N. Barnes, H. Bada, and J.R. Pauly. 2006. Neural precursors as preferential targets for drug abuse—long term consequences and latent susceptibility to CNS disorders, In Alcohol & Nicotine and CNS Development (Michael W. Miller, Ed.), Oxford University Press


6. Milatovic, R. C. Gupta, S. Zaja-Milatovic, G. N. Barnes and M. Aschner (2009) “Involvement of Oxidative Stress and Dendrogenesis in Anticholinesterase Pesticide Neurotoxicity”. In Anticholinesterase Pesticides: Metabolism, Toxicity, and Epidemiology, editors: Tetsuo Satoh and Ramesh Gupta; John Wiley and Sons, Publishers


7. Barnes G., Sidhu R., Tuchman R.(2012): “Epilepsy.” In: Volkmar F. (Ed.) Encyclopedia of Autism Spectrum Disorders: SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg, -1. DOI: 10.1007/SpringerReference_344033 2012-12-12 14:45:19 UTC


8. Sidhu, R., Barnes, G., Tuchman, R (2012): “Antiepileptic Drugs”. In Volkmar F. (Ed) Encyclopedia of Autism Spectrum Disorders: SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg, -1. DOI: 10.1007/SpringerReference_344697 2012-12-12 14:45:11 UTC


9. Tuchman, R., Barnes, G., Sidhu, R. (2012): “Seizure” In Volkmar F. (Ed) Encyclopedia of Autism Spectrum Disorders: SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg, -1. DOI:

10.1007/SpringerReference_344191 2012-12-12 14:48:28 UTC

Selected Abstracts (since 2005)
1. G. N. Barnes, E. Schauwecker, E. Solis, X. Zhang, G. M. Smith, and G. C Mathews. (2005) Synaptic Regulatory Pathways for Neuropilin 2 Gene Expression- Implications for Aberrant Hippocampal Synaptogenesis, Epilepsia, in press 2. G. N. Barnes, C. Gant, O Thimbault, E. Balock, E. Schauwecker, R. Mervis, A. Bachstetter, J. Kotick, K. Hauser, G. M. Smith. (2005) Genetic Background Influences Hippocampal Synapse Formation and Hyperexcitability in the Neuropilin

 

2. KO Mouse, 2005 Abstract Viewer/Itinerary Planner, Washington, D.C.:Society for Neuroscience, 2005. Online

 

3. Barnes, GN, Zhang, X, Li, Y, Hauser, KF, and Dennis, KE. Genetic regulation of Sema 3F signaling modulates GABA signaling in murine hippocampus. Program Number 131.17/D14. 2007. Neuroscience Meeting Planner. San Diego, CA, Society for Neuroscience. Online

 

4. Barnes, GN, Zhang, X, Li, Y, Hauser, KF, and Dennis, KE. Genetic Regulation of Sema 3F signaling modulates GABA Neurons in Murine Hippocampus. Epilepsia Supplement (Abstract 3.033), 2007

 

5. G. N. Barnes, Y. Li, M. Aschner. Genetic regulation of murine semaphorin 3f signaling modulates hippocampal gabaergic circuitry: implications for gene-environment interactions. Program No. 325.2/B29. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.

 

6. Juliann Paolicchi, Gregory Barnes and B. Malow (2008) Abnormalities in Overnight Sleep EEGS in Children with Austistic Spectrum Disorders. Epilepsia 0 Suppl. 0 (Abst. 2.036 ), 2008

 

7. Gregory Barnes, Y. Li and M. Aschner (2008) Genetic Regulation of Murine Semaphorin 3F Signaling Modulates the Development of Hippocampal GABAergic Circuitry. Epilepsia 0 Suppl. 0 (Abst. IW.45), 2008

 

8. Gregory Barnes, Terry Jo Bichell, Sairey Siegel, Yanfang Li, Kevin Haas (2009) Putative role for the ubiquitin ligase ube3a during the development of gabaergic interneurons. Program No. 328.2/G17, 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online.

 

9. Gregory Barnes, Cary Fu, Daniel Lai and Alexandra Popescu (2010) Defining the Characteristics of Distinct Neurological Diseases in Patients with Autism Spectrum Disorders and Epilepsy. Poster number 118.166. International Meeting for Autism Research. Philadelphia, PA. International Society for Autism Research, 2010. Online


10. Gregory Barnes, Cary Fu, Daniel Lai and Alexandra Popescu (2010) Defining the Characteristics of Distinct Neurological Diseases in Patients with Autism Spectrum Disorders and Epilepsy. Poster. American Neurological Association. Philadelphia, PA. Annual Meeting, 2010. Online


11. Gregory Barnes, Yanfang Li. “Cell Specific Regulation of Semaphorin 3F Signaling Modulates GABAergic Circuitry” Cold Spring Harbor Proceedings, Axon Guidance, Synaptic Plasticity and Regeneration Meeting III, Cold Spring Harbor, NY, USA. 2010


12. Gregory Barnes, Yanfang Li, Sairey Siegel. Cell specific ablation of PTEN alters GABAergic circuitry, Program No. 334.6/D12. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.


13. Gregory Barnes, Yanfang Li, Sairey Siegel. “Cell SpecificRegulation of PTEN Signaling alters Cortical GABAergic Circuitry”. Epilepsia 0 Suppl.0 (Abst. 3.348), 2010. San Antonio, TX


14. Gregory Barnes, Juliann Paolicchi, Kaewen Adkins, Beth Malow. (2011) “The Relationship of Epileptiform Discharges to Sleep, Cognition, and Behavior In School Age Children with Autism Spectrum Disorders.” San Diego, CA. International Meeting for Autism Research, Online. 2011


15. Gregory Barnes, Reet Sidhu, Traci Clemons, Dan Coury. (2011) “Medical Comorbidities in Children with Epilepsy and Autism Spectrum Disorders.” San Diego, CA. International Meeting for Autism Research, Online. 2011

16. Gregory Barnes. (2012) “Genotype Phenotype Interactions of Epilepsy in Children and Adolescents with Autism Spectrum Disorders," Toronto, Ontario. International Meeting for Autism Research, Online. 2012


17. Gregory Barnes, Peggy Winzenburger, Akur Doshi. “Novel Relationships of Epileptic Discharges to Cognition and Behavior in an Animal Model of Autism and Epilepsy," Program No. 326.17/B21. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012.

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